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With
the launch of two DNA tests for the Staffordshire Bull Terrier, namely
for L-2 Hydroxyglutaric Aciduria (L-2HGA) and Hereditary Juvenile Cataract
(HC) breeders are faced with a decision either to breed or not to breed
from carrier stock identified by these DNA tests.
Professional genetic advice has been sought from both the Kennel Club and the Animal Health Trust regarding the use of breeding stock identified by the DNA tests. We are advised that most benefit for a Breed is derived by using the DNA tests with a long term plan rather than a quick fix which might result in other long term problems. It is their view that DNA test results alone should not be the driving factor when planning matings, that the dog as a whole is taken into consideration, and that the long term health of the Breed is best served by using the DNA tests to avoid breeding affected dogs from a given mating not merely to exclude carriers from the breeding programme. It should be long term goal to reduce the number of carrier stock in the breeding population to either zero or negligible levels. The recommendations below have been compiled to reflect this advice. It has been agreed by the Kennel Club Finance and General Purposes Committee that when dogs have been DNA tested their names will subsequently appear in the Kennel Club Breed Records Supplement, and on the Kennel Club website stating whether they are either clear or carrier or affected. In the future registration documents will include this information where applicable, and dogs bred from parents that are DNA tested clear will be identified as hereditarily clear. When dogs are identified as hereditarily clear for these two conditions further DNA testing is not required. It is worth remembering that the genetic status of dogs that are not either DNA tested or bred from parents that are DNA tested (hereditarily clear), is unknown, unless of course they themselves are affected. Recommendations 1) All breeding stock should be DNA tested for both L-2 Hydroxyglutaric Aciduria (L-2HGA) and Hereditary Juvenile Cataract (HC) before they are bred from, unless they are from parents shown to be hereditarily clear. (See note 1).. 2) Identified carriers should not be mated to an untested dog, or to another identified carrier or to an affected dog. 3) If identified carriers are mated, it should only be to a DNA tested clear dog or a dog that is proven to be hereditarily clear.(See note 1) 4) If breeders choose to mate a DNA tested carrier dog to a DNA tested clear or hereditarily clear dog (See note 1), then they must undertake to DNA test the resultant puppies to identify their genetic status. The breeder has two options here: (a) All the puppies are DNA tested prior to re-homing, the identified carriers should then be endorsed by the breeder, “Progeny not eligible for registration”. (See note 2) Or : (b) All puppies from such a mating should be endorsed “Progeny not eligible for registration” until such time as they are DNA tested, after which time puppies identified DNA tested clear can have the endorsement lifted by the breeder. (See note 2) Note1. Hereditarily clear means that a dog has been bred from parents that are either (a) both DNA tested clear, or (b) parents that are registered as hereditarily clear . Note 2. Endorsements should be placed using the following guidelines |
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